At present, the objective of Hydrocracking is to convert medium and heavy vacuum gas oil (VGO) and possibly deasphalted oil (DAO) or demetallized oil (DMO) into gasoline lines, jet fuels and diesel oils according to geographical and seasonal variations in demand. In some specific cases one can try to get Liquefied Petroleum Gas (LPG) and lubricating bases. The challenges that are posed on refiners are to employ the most suitable catalyst system that is capable of handling large hydrocarbon molecules and heavy poly-aromatic molecules. That certainly necessitates having large pores catalyst that can accommodate these large molecules and perform the desired reactions. As a result, various catalyst types were prepared throughout this work, at the same Nickel-Molybdenum metals loadings and zeolite to alumina binder compositions. This is an attempt to spot the appropriate catalyst support that can process VGO/DMO feed blend.