Alcohol is very toxic substance on a large scale. This means that high-level alcohol abuse is harmful to public health. It contributes to the global burden of disease, and it is the third major risk factor, leading to accumulation of toxins and damage to vital organs such as the liver and brain. Therefore, the objectives of this study are: 1- Evaluation of the toxic effects of alcohol on the liver and brain. 2- Evaluate the positive effect of water extracts on avocado fruit and mustard seeds are to relieve this toxicity. Male albino rats weighing 200-250 g were divided into five groups, five rats in each group as follows..