The present work has focused on the synthesis of some new bioactive quinoline derivatives starting from readily available 2-chloro-3-formylquinoline. The biological evaluation of the newly synthesized quinolines were done against some bacteria and fungi human pathogenic strains and also against four human tumor cell lines. The material presented in this work is divided into two main parts: Part l: Synthetic part 1. Synthesis and reactions of N΄-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide (105)...